Curt Connors, Mary Jane Watson and Aunt May appear only during a recap.
Vanessa Fisk appears only in a vision.
Peter Parker never wears the Spider-Man costume in this story.
Steve Lieber and Rachelle Rosenberg are not given credit, but appears to be their work on pages 15-17.
*Warning - Spoilers for the issue are contained below*
The Sinister Six members, Beetle (Janice Lincoln), Overdrive, Shocker (Herman Schultz) and Speed Demon do not actually appear in this issue. It's revealed in this issue that they are in fact LMD's created by the Tinkerer.